Short-term treatment 'could prevent osteoarthritis'

Posted on 05 September 2011

Treatment with glucocorticoid could prevent the long-term damage to joints which causes the osteoarthritis seen in many paying for care.

Research published in journal Arthritis Research & Therapy found that short term treatment of damaged cartilage with glucocorticoids was able to reduce long term degenerative changes, potentially leading to osteroarthritis.

Researchers subjected cartilage to mechanical injury and immune-stimulating bio-molecules and found that glucocorticoid dexamethasone (DEX) was able to reduce the loss of glycosaminoglycans and restore proteoglycan synthesis levels to normal.

Researcher Professor Alan Grodzinsky explained: "Our results suggest that short-term glucocorticoid treatment after joint injury may help restore components of cartilage to preinjury levels and consequently may prevent the long term changes which lead to osteoarthritis."

This follows comments from Neil Betteridge, chief executive of Arthritis Care, who said that obesity is one of the major causes of osteoarthritis, meaning that an increasing number of younger people may suffer from the condition.

Posted by Natalie Edwards



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