Researchers uncover Parkinson's mutation

Posted on 15 July 2011

Researchers have discovered a mutation which is associated with an inherited form of Parkinson's disease in a breakthrough which could help many with the condition who are paying for care.

Two studies published in The American Journal of Human Genetics explained that previous research identified pathogenic mutations in several genes in patients with familial parkinsonism. These have provided targets for therapeutic intervention.

Both research groups detected the same mutation in the vacuolar protein-sorting-associated protein 35 (VPS35) in two different families with multiple sufferers of the condition.

"A single variant in the VPS35 gene was found in all affected family members investigated, was absent in general population samples, and was detected in two additional PD families," say Dr Strom and Dr Zimprich, leaders of one of the studies.

In other news, research featured in a podcast series by the American Chemical Society used a 'needle-in-a-haystack' method to uncover potential new treatments for Parkinson's disease and other brain conditions.

Posted by Natalie Edwards

 

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