New substance to aid Alzheimer's patients?

Posted on 21 April 2011

A new way of delivering drugs to the brain could aid the treatment of people paying for care due to conditions such as Alzheimer's and Parkinson's disease, it has been revealed.

Scientists have identified a cholesterol blocking substance which is also able to breach the protective barrier surrounding the brain, according to the study published in journal ACS Chemical Biology.

Aleksey G Kazantsev and his team have previously found that blocking the formation of cholesterol in the brain could halt the progress of Parkinson's and other such conditions.

"[The findings] could have a broader application in other neurological conditions, such as Alzheimer's disease, for which modulation of cholesterol and other associated metabolic pathways might be of therapeutic benefit," wrote the authors.

Meanwhile, researchers from the Karolinska Institutet conducted research on salamanders that could lead to new Parkinson's treatments.

They investigated the salamander's tendency to replace missing dopamine-producing neurons and found that when the concentration is reduced, the animal's stem cells are activated and the missing neurons are restored.

Posted by Natalie Edwards

 

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