Enzyme inhibitor to slow progress of MS?

Posted on 02 September 2011

Suppressing the fuel used by inflammatory immune cells could slow the progress of multiple sclerosis (MS) - a condition suffered by many paying for care.

Researchers found that inhibiting the ability of immune cells to utilise fatty acids as fuel slowed the progression in a mouse model of MS, according to the paper published in journal Scientific Reports.

It was found that by inhibiting a single enzyme, which helps immune cells exploit fatty acids, the cells starved and died, meaning they could create no more inflammatory damage.

First author of the study Leah P Shriver commented: "We expect that because immune cells not in lesions in the CNS are able to use available glucose, they will function just fine during infection and that inhibition of this pathway would not produce general immune suppression."

This follows research carried out at the Dallas Veterans Affairs Medical Center which revealed that MS is not caused by a blood vessel condition, reports Reuters Health.

Despite previous research indicating that chronic cerebrospinal venous insufficiency could be linked to MS, the new analysis indicated it is not the cause.

Posted by Natalie Edwards

 

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